New breakthroughs, user success, and expert tips – all in one place
Welcome to MGI SEQALL Insights 2025
Welcome to the first edition of SEQALL Insights, MGI Australia's brand-new bi-monthly update on the latest in multi-omics! Curated to bring you the latest advancements—without flooding your inbox. Expect a fresh edition every two months with insights on the themes and topics that matter most to you. In this edition we cover:
✨Product Launches: Introducing DNBSEQ T1+, a highly efficient mid-throughput sequencer with Q40 accuracy, delivering 25Gb – 1.2Tb of data in under 24 hours; Stereo-seq mIF, a breakthrough in multi-modal spatial analysis, combining transcriptomics with protein detection to reveal deeper biological insights.
🧬Technology Spotlight: A deep dive into FluoXpert, the world's first platform that integrates high-resolution fluorescence imaging with next-gen sequencing ideal for advanced biomarker research.
🧑⚕️User Story: How a pioneer in specialty genetic testing is leveraging MGI technology to support healthcare providers in identifying the root causes of illness and advancing preventative medicine.
🛠️Tech Tips: STOmics Blog is live! Explore the latest Stereo-seq applications and latest publications. This feature is how STOmics empowers translational research and drug development. MGI ANZ launch new Tech Support email for dedicated customer support.
Let’s dive in! 🚀
| A Trailblazing Path to 24-Hour Sequencing DNBSEQ-T1+ 'Dolphin' Introducing DNBSEQ-T1+, also known as 'Dolphin', the next evolution in mid-throughput sequencing, delivering up to 1.2 Tb of data in under 24 hours with industry-leading Q40 accuracy. Whether you're driving breakthrough discoveries, scaling up for high-throughput projects, or optimizing costs, DNBSEQ-T1+ offers the speed, precision, and flexibility to power your genomics research. 🐬 All-in-One Simplicity – DNB Making, Sequencing and Analysis fully integrated with the DNB M&L module for one-click DNA nanoball (DNB) preparation and direct sequencing. ⚡ High Accuracy & Reliability – 100% run pass rate, >90% Q40 reads, and independent lane loading for optimized sequencing. 🔬 Flexible Multi-Application Workflow – Supports dsDNA, ssCirDNA, and DNB libraries, with three Flow Cell options (FCL, FCM, FCS) to independently run different read lengths or applications. ⏳ Unmatched Speed & Efficiency– PE150 completed within one day, SE50 within one shift, delivering equivalent data output in 1/4 of the time; 🖥 Built-in Bioinformatics - the T1+A model includes a built-in bioinformatics module for automated advanced analysis. From biodiversity studies to clinical breakthroughs, T1+ delivers speed, accuracy, and all-in-one efficiency for your genomics research. 👉Discover T1+ ‘Dolphin’ on the MGI Website |
We’re excited to introduce Stereo-seq Transcriptomics Solution V1.3 for mIF, a new STOmics advancement that integrates spatial transcriptomics with multiplex immunofluorescence (mIF) for deeper biological insights.
Product Highlights:
🔹Detect up to 4 protein biomarkers, provide unbiased high-resolution whole transcriptomics information, and assess RNA and protein spatial distributions in cells on the same fresh frozen tissue.
🔹 Offer flexibility in choosing antibodies based on your research needs and project design.
🔹Deliver single-cell resolution results across different species, enabling more robust and translatable scientific discoveries.
🔹Improved workflow and upgraded bioinformatic pipeline, providing a user-friendly experience.
👉 Learn more about Stereo-seq mIF on STOmics website
| World's First Sequencer with Integrated mIF DNBSEQ-G400RS FluoXpert integrates high-resolution fluorescence imaging with high-accuracy sequencing, enabling both multiplex immunofluorescence (mIF) analysis and next-generation sequencing on a single platform. Key Features: 🔹Q40+ Accuracy – Achieves ultra-precise base calling with minimal index hopping and low duplication rates. 🔹mIF Compatibility – Detects multiple protein markers on a single tissue section, preserving spatial architecture without sample loss. 🔹Gold-Standard Consistency – Produces mIF staining results comparable to IHC, ensuring high reproducibility for biomarker research. 🔹Advanced Optical & Imaging Algorithms – Enables precise antigen-antibody recognition, high-resolution tissue imaging, and minimal photobleaching. 🔹Flexible Sample type & Reagent Compatibility – Supports both frozen tissue and FFPE samples; supports commercial and custom-developed antibodies, allowing broad experimental adaptability. 🔹Efficient Workflow – Streamlined sample preparation, high-speed processing, and user-friendly automation 👉 Learn more about DNBSEQ-G400 FluoXpert on MGI website |
We hear from James Cavaggion, Director of NutriPATH Pathology, on how NutriPATH is pioneering microbiome testing and expanding personalised lab automation to support its commitment to innovation and high-quality diagnostics—in collaboration with MGI. Don't miss the full interview, now available on MGI’s YouTube Channel 🎥
Stereo-seq enables high-resolution spatial transcriptomics, offering unparalleled insights into gene expression at tissue and single-cell levels. To help users navigate Stereo-seq Analysis Workflow (SAW), we’ve compiled key FAQs addressing essential aspects of data processing and analysis.
- What is SAW, and what does it do?
- Stereo-seq Analysis Workflow (SAW) is a bioinformatics pipeline designed to process Stereo-seq data, map sequenced reads to their spatial locations, quantify gene expression, and generate high-resolution spatial gene expression matrices for downstream analysis.
- What input files does SAW require?
- SAW takes raw sequencing data (FASTQ files) and corresponding metadata (barcodes, spatial coordinates) to ensure accurate spatial positioning and gene quantification.
- What format should the FASTQ files be in?
- SAW supports Q40 FASTQ and Q4 FASTQ file formats.
- How do I choose the right bin size for analysis?
- Bin size selection depends on tissue type and resolution needs:
- -Bin20 (~size of a mammalian cell) for single-cell resolution.
- -Bin50 & Bin100 for commonly used analysis scales.
- -Bin200 for a broader view and rapid visualization.
📌 For a deeper dive into SAW and best practices, visit the full FAQ guide on STOmics Website.
| Full FAQ Guide |
📩 New ANZ Tech Support Email: mgi_anz_support@mgi-tech.com
We’re committed to providing you with timely and efficient tech support—reach out anytime!
MGI Australia & New Zealand
🎙 Topic: Introduction to Stereo-seq Transcriptomics Data Analysis
👨🏫 Speaker: Yahui Li, Field Application Scientist (Bioinformatics), STOmics
🔍 Highlights:
- In-depth overview of Stereo-seq technology
- Step-by-step guide to the data analysis workflow
- Live software demo with real-world data
STOmics Data Analysis Webinar
📍 MGI Australia & New Zealand
Level 6, CBCRC, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Brisbane, QLD 4006, Australia
📩 Email: MGI_Australia@mgi-tech.com
📞 Phone: +61 (0) 7 3362 0475
🔗 Website: en.mgi-tech.com
📢Connect with MGI on social media.
This email is for informational purposes only. Product availability, pricing, and intended use may vary by region. Please contact local team for details.
